Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids

This highlight review describes the syntheses of 2-azabicyclo[3.3.1]nonanes, focusing on synthetic studies macrocyclic diamine alkaloids, sarain A and madangamines. These alkaloids have a 2-azabicyclo[3.3.1]nonane that is fused with an N-heterocycle. Researchers employed unique strategies to construct different structures additional substituents functional groups in target molecule.